Bronchial astma och akupunktur

Av: Acupuncture Research Resource Centre, published by British Acupuncture Council

BRONCHIAL ASTHMA AND ACUPUNCTURE: THE EVIDENCE FOR EFFECTIVENESS

This paper reviews a number of clinical trials and outcome studies on the use of acupuncture to treat asthma. None of the trials had a large sample size and they suffer from the problems common to all acupuncture trials, such as what constitutes appropriate treatment and a suitable “control”. The outcome studies avoid some of these problems but many lack rigour or adequate description of measurements used.

This paper reviews the trials that appeared most sound in methodological terms, together with those outcome studies that had relatively large samples. The trials are divided into two groups: those treating patients as part of normal clinical management and those treating patients suffering an induced asthma attack. The findings for the first group are inconsistent, particularly as regards objective measures of lung function. There is, however, evidence that acupuncture can improve patients’ subjective experience of their symptoms, reduce their use of medication and improve immunological parameters. The smaller number of trials of induced asthma is more consistently positive. The majority of trials provide an inadequate rationale for the acupuncture points used and few bear any relationship to the way acupuncture is actually practised by British Acupuncture Council members. The outcome studies generally provide a much better picture of the diagnostic criteria used and show more consistently positive results than the trials, but their methodology is often weak. The paper concludes by discussing some of the issues that need to be addressed in developing clinically relevant and methodologically sound research.

Introduction.
It is estimated that asthma affects approximately 10% of the population. Both incidence of the disease and resulting mortality are increasing (Howell, 2000). The definition of “asthma” is not, however, clear-cut. Howell (2000) identified three elements: reversible airways obstruction with episodic attacks of breathlessness accompanied by wheezing; responsiveness to asthma drugs (cromoglycate and/or corticosteroids); bronchial hypersensitiveness. In practice, however, none of these provides an absolute criterion for distinguishing asthma from other breathing problems and asthmatics are defined as those with reversible airways obstruction and/or clear responsiveness to asthma medication. The management of asthma often requires daily use of medication on a prophylactic basis. Severe attacks may require hospitalisation and can lead to death. Asthma thus has high economic and personal costs. Lewith and Watkins (1996) suggested that asthma costs the NHS about £400 million per annum; the Department of Social Security, in the form of sickness benefits, £60 million; the economy as a whole, in terms of lost productivity, £350 million.

Literature Search
A search was carried out using the ARRCBASE, the Acupuncture Research Resource Centre
database of articles drawn from the British Library’s AMED and the US MEDLINE, using
the terms “asthma”, “breathlessness” and “acupuncture”. Sixty-one references were
identified and an additional twenty-two were derived from citations in these papers. Papers
were excluded for variety of reasons: no English translation was available; the paper was
unobtainable from the British Library; the paper was not primarily concerned with presenting
or reviewing clinical evidence; the study involved therapies other than acupuncture or did not
use needles.

The remainder could be grouped into three categories: reviews, descriptions of a randomised
controlled trial (RCT) and descriptions of an outcome study. Reviews were only included if
they had been published after 1990, on the grounds that earlier publications would have been
superseded. Some RCTs were excluded on the grounds of their weak methodology. For trials
prior to 1990, the system of evaluating methodological quality set out by Kleijnen et al
(1991) was used to exclude those which scored below 40. Trials since 1990 were included if
fully randomised. Outcome studies were included if they used significantly larger sample
sizes than the RCTs. The papers finally selected comprise 6 reviews, 11 controlled trials, and
four outcome studies.

Reviews
Two of the reviews (Kleijnen et al (1991) and Linde et al (2000)) focused on the
methodological quality of the trials reviewed. Kleijnen et al (1991) reviewed 13 trials, which
were evaluated against 18 predefined methodological criteria and scored out of 100. Only 8
studies scored above 50 and no paper scored above 72, leading the authors to conclude that
no conclusion as to acupuncture’s effectiveness could be drawn due to the poor quality of the
trials. A similar conclusion was reached in the most recent review carried out by Linde, Jobst
and Panton (Linde et al 2001) as part of the Cochrane Collaboration. This review involved
tight selection criteria: of 21 trials identified, only seven were regarded as worthy of
inclusion. The aim of the Cochrane collaboration is to provide overall analyses that can show
conclusively whether there is evidence in favour of particular medical interventions. The
authors argued that the heterogeneous nature of the acupuncture trials precluded such an
analysis.
Both these reviews proposed that there was no conclusive evidence that acupuncture has a
significant effect on the course of the condition – but equally there is no evidence that it does
not. In effect, these reviews are an argument for more rigorous research. Until then, the “jury
is out”.
The remaining four reviews (Linde et al (1996), Jobst (1995, 1996), Lewith and Watkins (1996)) analysed a range of individual trials, all of which involved some comparison of a treatment group receiving true acupuncture with a control group receiving sham acupuncture. Table 1 summarises their findings.
These reviews highlight the difficulty in reaching agreement, partly because of the heterogeneous nature of the trials themselves and partly because of differences in the subjective interpretation of the reviewers. For example, Linde et al (1996) used a set of assessors to evaluate both the methodological validity of the trials and the appropriateness of the acupuncture treatments used. Whilst their assessors reached a high level of agreement on the internal validity of the trials, there was little agreement amongst them as to whether the acupuncture treatments given were appropriate; also, the outcome measures used varied

Table 1: Reviews of Acupuncture
Author Number of Conclusions
trials reviewed

Linde et al 14 True acupuncture superior to sham: 5
(1996) Trend in favour of true acupuncture: 2
No difference between true and sham: 6
Sham acupuncture superior: 1
Jobst (1995, 16 True acupuncture superior: 10
1996) No difference: 3
Equivocal: 3
Lewith and 10 9 positive on at least some outcome
Watkins measures
(1996)

considerably. Furthermore they disagreed with Kleijnen et al (1991) in some of their assessments as to whether or not individual trials showed positive results. Similarly, Jobst (1995,1996) differs from Linde et al (1996) in the interpretation of the results of two trials.

In summary, three of the reviews, Kleijnen et al (1991), Linde et al (1996) and Linde et al (2000), argued that the trials did not enable us to come to any conclusions about acupuncture’s effectiveness, whilst three, Jobst (1995,1996) and Lewith and Watkins (1996), considered that there was evidence of effectiveness. Jobst (1995,1996) suggested that acupuncture might be used as an addition to conventional medical management of asthma and could lead to a reduction in the need for medication, particularly corticosteroids. Lewith and Watkins (1996) concluded that acupuncture could be useful in the alleviation of short term, acute airways obstruction but that evidence for its long-term efficacy was more open to question – largely, however, because the majority of the trials failed to include any long-term follow-up.
The next sections will review in more detail some of the RCTs discussed in the above reviews
as well as outcome studies, which, being uncontrolled, are rarely considered in systematic
reviews.

Randomised Controlled Trials
Eleven trials were selected, of which four concern acupuncture administered shortly after the onset of induced asthma, whilst the remainder cover acupuncture provided under normal clinical conditions. Clearly, the latter are of greatest interest to practitioners since most asthmatics encountered in the treatment room will have their asthma managed through drugs and practitioners may very rarely treat a severe acute attack. Of more interest will be issues such as whether acupuncture can lead to a reduction in medication. Nevertheless, the studies of induced asthma are of interest if they can demonstrate whether acupuncture has an effect.

Trials of treatment given under normal clinical conditions.
Characteristics of trials
The trials detailed in Table 2 all involved patients with a diagnosis of chronic asthma, apart from Jobst et al (1986) where the diagnosis was Chronic Obstructive Pulmonary Disease, and only four of the subjects had signs of asthma. This paper was included since it appears in all the reviews of trials of asthma. The outcome measures used in the studies varied. All but Joos et al (2000) included measures of lung function. Other measures included:

• medication use
• immunological parameters
• heart rate and blood pressure
• walking distance (Jobst et al (1986) only)
• subjective relief of symptoms
• subjective well-being, quality of life measures.

The details of the outcome measurements used are included in the footnote to Table 2.

Table 2: Controlled Trials for Chronic Asthma
Design Sample Number Treatment Outcome Conclusion
type size of tx (appropriate Measures
acupuncture
listed first)
Christensen Double 17 10 over Ren 17, LI4, Lung function: MPEFR, Modest effect of appropriate acupuncture on both
et al (1984) blind five weeks Dingchuan, Bl EPEFR Medication: no. of objective and subjective measures of lung function
13 vs sham. puffs of â-agonist and one immunological parameter. More substantial
Subjective: DSA, WSA effect on medication use.
Immunological: IgE, IgG, IgA,
IgM
Dias et al Double 20 Variable Ren 22, Lung function: PEFR Improvements in both groups but control group better
(1982) blind Dingchuan, Lu 7 Level of medication usage than appropriate acupuncture.
vs GB 5 & 6

Jobst et al Single 26 13 over Individual TCM Lung function: PEFR, FEV1, No change in lung function. Significant improvement
(1986) blind three treatments vs FVC in well being and walking distance for appropriate
weeks sham Subjective well-being acupuncture.
Subjective measures of
breathlessness.
Walking distance: six minute
walk.

Mitchell & Single
Wells blind
(1989)

Tashkin et Single
al blind
(1985)

Biernacki & Double
Peake blind
(1998)

31 8 over 12 Ren 17, Bl 13,
weeks Liv 3 vs Sp 8, Ki
9,GB37.

25 8 LI 4, St 36, Du
over 14, Lu 7,
4
Dingchuan,
week
s, Waidingchuan vs
then sham.
cross
over
23 1 Ren 17 vs sham
treatment point on the
followed chest wall.
by
crossover.

Lung function: PEFR
Medication use
Asthma symptoms: patient
report
No. of Asthma episodes
Lung function: SGaw,
spirometry.
Diaries of medication use &
subjective symptoms.
Heart rate and BP.

Lung function: FEV1, FVC.
Medication use
Quality of life questionnaire.

Improvements in both groups. No statistically
significant difference between them. Appropriate
acupuncture group had no asthma episodes compared
with four in control.

Trend to improvement in both groups but not
statistically significant.

No improvement in lung function, both groups had
improved quality of life and reduced medication.

Joos et al Single 38 12 Bl 13, 17, Ren Immunological parameters: 14 Significant improvement in general well-being and
(2000) blind treatments 17, LI 4, Lu7 measures used. most immunological parameters for appropriate
over 4 plus General well-being (patient acupuncture.
weeks individualised report).
points vs
inappropriate
points *

* The inappropriate points also included both a set of basic points for all patients (TE3, 19, GB 8, 34) and randomly assigned flexible points (Bl 38, 55, St 4, 6, 32, TE 14, 23, SI 5).

Key to abbreviations: MPEFR (morning peak expiratory flow rate), EPEFR (evening peak expiratory flow rate), PEFR (peak expiratory flow rate), FEV1 (forced expiratory volume in one second), FEF50 or 75 (forced expiratory flow after 50% or 75% vital capacity exhaled), Raw (airway resistance), SGaw (specific airway conductance), DSA (daily severe asthma scale), WSA (weekly severe asthma scale), BP (blood pressure).
Methodologically, it is extremely problematic to design a double blind trial in which both
patient and practitioner are blinded. If the treatment is provided by a trained practitioner,
even if they are given sets of points to needle by a different practitioner, they may be able to
identify whether points are inappropriate or appropriate for the condition being treated.
Where sham points are used, the problem is insurmountable. In practice, therefore, the trials
described in Table 2 as “double blind” have blinded the patients and used a blinded
evaluator but the practitioner providing the treatment is not necessarily blinded. There may
therefore be little difference between trials which describe themselves as double or single
blind.
The majority of the trials involved some sort of period during which baseline measurements of parameters such as lung function were drawn up, followed by a treatment period, followed by further measurements. The majority did not involve any long-term follow-up of patients. Two trials (Biernacki and Peake (1998), Tashkin (1985)) used a crossover design, whereby patients were randomly assigned to real or placebo acupuncture, followed by a washout period, followed by a second treatment phase during which they received the alternate form of acupuncture to the one received in the previous treatment phase.

As for the actual treatment given, it is unfortunate that the RCT design has come to be associated with the idea of standard treatments. Whilst this constraint has been more open to question in recent years, only two of the trials below included any individualisation of treatment. In one (Jobst et al (1986)) treatment was fully individualised according to TCM (Traditional Chinese Medicine) syndromes whilst in the other (Joos et al (2000)) both standard and individualised points were used. The control group received either sham acupuncture (points with no defined energetic effect) or what were defined as inappropriate acupuncture points. Researchers differed as to whether they thought the control points should be located reasonably close to the “real” points or at some distance.

All trials except Dias et al (1982) gave a standard number of treatments, which varied from one (real) treatment in Biernacki and Peake (1998) to thirteen in the Jobst et al (1986) study. The number of treatments in the Dias et al (1982) study varied from 2 to 8 (median 6) in the control group and 4 to 12 (median 6) in the treated group.

Findings
As regards objective outcome measurements, six of the seven trials measured lung function,
and, in four, patients experienced improvements in lung function. However, one of these
favoured inappropriate acupuncture over appropriate acupuncture and two failed to show a
statistically significant change. Only one, therefore, unequivocally favoured appropriate
acupuncture. Two of the trials looked at immunological parameters, both of which
demonstrated positive benefits for appropriate acupuncture. Joos et al (2000) reported
positive changes in a number of immunological parameters, although only the increase in in
vitro lymphocyte proliferation rates reached statistical significance when comparing the
TCM group with the control group. Christensen et al (1984) reported reduced levels of IgE in
the true acupuncture group.

Turning to subjective indicators, six of the trials used measures such as general well-being, quality of life or subjective experience of symptoms. All showed patients experiencing
benefits, with three showing appropriate acupuncture superior to inappropriate and three showing improvements in both groups. The relative importance of objective and subjective measures is debated: Jobst et al (1986) argued that acupuncture was helpful in reducing disability since the subjective experience of breathlessness and ability to walk for six minutes improved significantly even without there being a corresponding change in objective measures of lung function.

In relation to all these trials we should bear in mind that they had small sample sizes and only two made any attempt to include some element of individual diagnosis. Both of these (Jobst et al (1986), Joos et al (2000)) included positive outcomes. The problem of diagnosis and point choice will be discussed further later.

Trials of acupuncture for induced asthma attacks.
Three trials looked at the effects of acupuncture on people with a history of asthma, but where bronchospasm had been induced, either by exercise (Fung et al (1986), Chow et al (1983)) or by inhalation of methacholine (Tashkin et al (1977)). A fourth (Yu & Lee (1976)) looked at acupuncture as a treatment for spontaneous asthma attacks, but a sub-group of four patients had an attack induced by histamine inhalation whilst in remission. Table 3 summarises the trial characteristics.

Table 3: Controlled Trials for Induced Asthma
Design Sampl No of tx Treatment Outcome measures Conclusion
e size
Chow Single 16* 1 before Auricular points: Lung function: FEV1, FVC. Neither gave protection against asthma.
et al blind exercise* lung area vs
(1983) lumbago area.
Tashkin Double 12 1 after LI4, Du14, Lung function: FVC, FEV1, Real acupuncture better than sham although
et al blind, induced Dingchuan, FEF25-75, FVC, Sgaw, Raw, Vtg. isoproterenol was most effective.
(1977) crossov broncho Waidingchuan, Blood pressure.
er spasm St36, Lu7 vs Heart rate.
sham
acupuncture
Fung et Single 19** 1 before Dingchuan, L6, Lung function: FEV1, FVC, Real acupuncture gave greater protection than sham.
al blind exercise K3 vs SI14, P4, PEFR.
(1986) GB39.
Yu & Single 20 1 during St 36 (both Lung function: FEV1, FVC, Dingchuan showed significant benefit compared with
Lee blind spontaneou groups) vs PaCo2 both sham and St36 during spontaneous asthma
(1976) s attack. Dingchuan, vs Subjective breathlessness attack.
1 before sham Heart rate
and 1 after Expiratory wheeze.
induced
attack

* all aged 8 – 13. Needles left in during exercise. ** all aged 9 – 13.5 years
Abbreviations: as Table 3 + PaCo2 (arterial carbon dioxide pressure) and Vtg (thoracic volume at functional residual capacity).
© Acupuncture Research Resource Centre and the British Acupuncture Council

Findings
Three of the four trials showed positive findings regarding relief of bronchospasm by acupuncture, although Tashkin et al (1977) found that medication had a stronger effect. Yu and Lee (1976) found acupuncture to be beneficial in terms of both subjective and objective parameters for spontaneous asthma attacks, but not effective for histamine-induced attacks. This study is of particular interest because of the comparison of the effect of the extra point Dingchuan with both St 36 and a non-acupuncture site. Nine of the 10 patients in the group treated with Dingchuan experienced relief from breathlessness. This was superior to the nonacupuncture site, which was located 4 cms lateral to Dingchuan. The point St 36 was least effective, with only one out of 20 patients reporting any benefit.

Outcome Studies
Four outcome studies have been included. These are summarised in Table 4.

Findings
Three of the outcome studies are particularly useful because they provided for individualised treatments and explained the diagnostic criteria used in the choice of points. The studies all demonstrated very positive results, but a weakness is that the baseline and outcome measures are often unclear. Where specific measures were referred to, actual statistics were rarely given, instead rather vague categories, such as “markedly improved”, were used. An exception is the experimental group in the Shao Jingming study.

Conclusion
Whilst three of the four trials of induced asthma showed the acupuncture conferred statistically significant improvements in objective and subjective symptoms, the findings of the trials for asthma as part of normal clinical practice were more mixed. Nevertheless, they demonstrate evidence for the efficacy of appropriate acupuncture for some immunological parameters, for experience of asthma symptoms, level of medication use and quality of life. Findings are more equivocal for improvements in objective measures of lung function with only one, Christensen et al (1984), finding a statistically significant effect in favour of appropriate acupuncture. One, Dias et al (1982),

Table 4: Outcome Studies

Sample Number of Acupuncture
size treatments
Zang 192 Single treatment Lu 6 & Lu 10 with electro acupuncture
Junqi
(1990)
Lai 143 Treated for six Bl 13, 20, 23, Du 14, Ren 15, 22 (all)
Xinsheng months Dingchuan or St 40 for excess type. Bl 43, Ren
(1993) 4 (sometimes with moxa) for deficiency type.
Shao 111 Daily then alternate Bl 12, 13, Du 14 (all). Lu 5,9 (cough). Ren 12
Jingming days over ten days. St 36 (sputum). Bl 23, Ren 4, Ki 3 (kidney
(1985) Repeated where deficiency). Moxa used for cold symptoms,
necessary. cupping for heat. Dietary restrictions.
Landa & 2,500 9-12 sessions per Individualised according to eight principles, but
Fadeeva children course. no information on actual points used.
(1992) not all
had
asthma

Outcome measures Results

Clinical observation of symptoms and 76.5% clinical
signs such as dyspnoea, wheezing but not remission or marked
clear how measured. improvement.
Asthma, chest distress, dyspnoea, cough, 89.8% short-term
expectoration, wheezing and cyanosis. Not cure or markedly
clear how measured. effective.
Reference to symptoms but not specified. 98.2% were
Lung function tests in experimental group improved or
* markedly improved

Observed improvements in asthma Positive effect for
symptoms plus various objective 87% of all patients.
measures: suprarenal and hypophysis
functions, immune status, tryptophan
exchange, physical development.

* A comparison of the effects of Bl 13, Du 14 and Bl 12 using acupuncture with cupping, acupuncture with moxa and no treatment showed the greatest
improvement for acupuncture with cupping. They also compared Bl 13, Du 14 and Bl 12 and found that Bl 13 gave the best results.

found in favour of the control group, which received “inappropriate” acupuncture. This leads some researchers, e.g. Grebski et al (1999), to argue that acupuncture is a useful placebo but that the exact location of the needles is unimportant.

Three counter-arguments can be made. Firstly, as Joos et al (2000) point out, inappropriate acupuncture is not a placebo since it has definite physiological effects. “True” acupuncture would, therefore, have to show a greater effect to achieve statistical significance than if it were being compared with an inert placebo. Secondly, a number of trials showed “real acupuncture” to be
superior and the study by Yu and Lee (1976) indicates that, in an acute attack of asthma, it
makes a great deal of difference where the needle is inserted, with the point Dingchuan
showing a markedly more positive effect than two other points. Thirdly, the majority of the
trials used standardised formulae with no attempt at individual diagnosis. Appropriate points
included points on the lung, large intestine, kidney, liver and stomach channels together with
Ren 17 and 22 and the Back-shu point of the lung, but there was rarely any clear rationale for
the choice. Stomach 36, for example, was used by Tashkin et al (1977, 1985) as a “real point”
whereas Yu and Lee (1976) found that it was no better than a sham point. Most traditional
acupuncturists would, therefore, regard these trials as of little help in understanding the
potential role of acupuncture as it is actually practised. The outcome studies bear a closer
relationship to the practice of traditional acupuncture and also demonstrate very positive
results. However, they suffer from poor design. Further studies are clearly needed which
combine both rigorous research methods and good quality acupuncture treatment. There is no
reason why outcome studies cannot use well-validated tools to clearly specify the base line
and outcome measures rather than using vague terms such as “significant improvement”. It is
also argued by many that pragmatic RCTs, where the acupuncture treatment is left to the
practitioner’s discretion and the control group receives an alternative form of treatment or no
treatment at all, are more useful than placebo-controlled trials because they enable
acupuncture to be studied as it is actually practised. “We think it more important to know if
acupuncture is of value for the patient than to know that it is ‘more than placebo’” (Linde et
al, 1996).

References
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Fung KP, Chow OKW, So SY. (1986) Attenuation of exercise induced asthma by acupuncture. Lancet. December 20-27: 1419-1421.
Grebski E et al (1999) Long-Term Effects of Real and Sham Acupuncture on Lung Function and Eosiphilic Inflammation in Chronic Allergic Asthma: Randomised, Prospective Study. European Respiratory Journal 14:507s (abstract only).

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Grateful acknowledgement is made to Jennifer Dale for her work in preparing this briefing paper

Publicerad: |2007-03-11|